Author

Fushun Zhang

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-0696-8907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Yan XiangiD· 4 shared Bibekananda SahooiD· 1 shared Chen Zhang· 1 shared Chengchao DingiD· 1 shared Chengjin YeiD· 1 shared Craig E. CameroniD· 1 shared David W. GoharaiD· 1 shared He LiiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

Yan XiangORCID

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4 papers

Recent·Most cited

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic Dysregulation

Zongjun Mou, Fushun Zhang, Marisol Morales, Bibekananda Sahoo, Xinghong Dai, Yan Xiang

This study determines the structural basis of SAMD9 autoinhibition and explains how pathogenic mutations disrupt this mechanism to cause disease.

Science Advances · Sep 23, 2026Peer-reviewedBiophysics

Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability

He Li, Yuan-Wei Norman Su, Fushun Zhang, Ibrahim M. Moustafa, David W. Gohara, Chengjin Ye, Luis Martínez‐Sobrido, Jamie J. Arnold, Craig E. Cameron, Yan Xiang

This paper shows SARS-CoV-2 can tolerate reduced proofreading activity but requires a minimal ExoN activity threshold for viability, leading to a mutator phenotype and reduced replication efficiency.

Journal of Virology · Jul 29, 2026Peer-reviewedMicrobiology

Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutations

Chengchao Ding, Xinyi Ashley Liu, Fushun Zhang, Saori Uematsu, Shu‐Bing Qian, Yan Xiang

This study identifies SLFN14 as a ribosome-associated endoribonuclease that represses translation by selectively cleaving type II tRNAs, and shows how mutations linked to thrombocytopenia disrupt this mechanism.

bioRxiv · Feb 4, 2026 · PreprintMolecular Biology

Structural and Functional Studies of Rabbit SAMD9 Reveal a Distinct tRNase Module That Underlies the Antiviral Activity

Juhi Chaturvedi, Fushun Zhang, Chen Zhang, Sonal Badhe, Yan Xiang, Junpeng Deng

This study identifies a distinct tRNase module in rabbit SAMD9 that retains antiviral activity despite structural differences from human SAMD9.

PLoS Pathogens · Jul 31, 2025Peer-reviewedBiochemistry