Ibrahim M. Moustafa

This paper shows SARS-CoV-2 can tolerate reduced proofreading activity but requires a minimal ExoN activity threshold for viability, leading to a mutator phenotype and reduced replication efficiency.

This study identifies a fold switch in ONNV nsP4 that regulates its conformation, RNA binding, and polymerase activity through proteolytic cleavage and fold switching.

This paper investigates how enteroviral RNA-dependent RNA polymerases perform forced-copy-choice RNA recombination, showing the role of a plus-one intermediate and preference for CMP over other nucleotides.

This study identifies a poliovirus nonstructural protein 3CD with an LIR motif critical for non-lytic spread via autophagosome incorporation and trafficking.