Glucagon dysfunction in the liver induces hyperplasia of PP cells and the production of glucagon and pancreatic polypeptide double-positive cells
Yuko Nakagawa, Takuro Horii, Ayako Fukunaka, Takashi Sato, Masaki Kobayashi, Tadahiro Kitamura, Yoshitaka Hayashi, Takashi Nishimura, Izuho Hatada, Yoshio Fujitani
The paper shows that glucagon dysfunction in the liver leads to PP cell hyperplasia and the emergence of GCG+ PP+ double-positive cells through hyperaminoacidemia and mTOR signaling.
bioRxiv · Feb 27, 2025 · PreprintCell Biology