Takashi Nishimura

Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification

This study identifies CTHRC1 as a protective factor in valvular interstitium that limits macrophage-driven calcification in aortic valve disease.

Microbiome-host interactions drive a trade-off between sleep quality and lifespan in Drosophila

This study shows that microbiome-host interactions in Drosophila create a trade-off between sleep quality and lifespan through specific bacterial metabolites and host responses.

Genome-wide association study shows developmental robustness control by intestinal maltase via internal environment in Drosophila

This study identifies Maltase as a key mediator of developmental robustness in Drosophila by modulating glucose availability and insulin signaling.

Glucagon dysfunction in the liver induces hyperplasia of PP cells and the production of glucagon and pancreatic polypeptide double-positive cells

The paper shows that glucagon dysfunction in the liver leads to PP cell hyperplasia and the emergence of GCG+ PP+ double-positive cells through hyperaminoacidemia and mTOR signaling.

Arrayed CRISPRi library to suppress genes required for Schizosaccharomyces pombe viability

The paper constructs CRISPRi libraries to knock down essential genes in S. pombe, revealing metabolic pathway interactions and enabling functional studies of essential genes.