Author

Klaus Lieb

University Medical Center of the Johannes Gutenberg University MainzORCID 0000-0002-9609-4261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 3 Approach:experimental assay· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jan EngelmanniD· 3 shared Marianne B. MuelleriD· 3 shared Nils C. GasseniD· 3 shared Abigail D. PowersiD· 2 shared Adrián I. CamposiD· 2 shared Adriana LoriiD· 2 shared Akitoyo HishimotoiD· 2 shared Alexis C. EdwardsiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Jan EngelmannORCID

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Author profile →

6 papers

Recent·Most cited

Dynamic Epigenetic Changes During Antidepressant Pharmacotherapy in Major Depressive Disorder

Svenja Müller, Josef Frank, Eric Zillich, Fabian Streit, Valentin Nicolai Koch, Miriam A. Schiele, Katharina Domschke, André Tadić, David P. Herzog, Stefanie Wagner, Marianne B. Mueller, Giulia Treccani, Nils C. Gassen, Marcella Rietschel, Stephanie H. Witt, , Lea Zillich

This study identifies DNA methylation changes over time during antidepressant treatment in MDD, linking them to neuroplasticity and inflammation, and shows differences between responders and non-responders.

bioRxiv · Nov 20, 2025 · PreprintGenomics

Spermidine alleviates depression via control of the stress response

Sarah Mackert, Christine Niemeyer, Yara Mecdad, Tim Ebert, Thomas Bajaj, Sylvère Durand, Sebastian J. Hofer, Andreas Zellner, Bianca Besteher, Jan Engelmann, Barbara Gisabella, Valerie Kempf, Lily A. Heckmann, Marcel Laakmann, Emily L. Newman, , Nils C. Gassen

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

bioRxiv · Dec 4, 2024 · PreprintNeuroscience

Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors

Anna R. Docherty, Niamh Mullins, Allison E. Ashley‐Koch, Xuejun Qin, Jonathan R. I. Coleman, Andrey A. Shabalin, Jooeun Kang, Balasz Murnyak, Frank R. Wendt, Mark J. Adams, Adrián I. Campos, Emily DiBlasi, Janice M. Fullerton, Henry R. Kranzler, Amanda V. Bakian, , Laura M. Thornton

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

medRxiv · Jul 3, 2022 · PreprintGenetic & Genomic Medicine

Rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) targets glucocorticoid receptor signaling: a longitudinal cerebrospinal fluid proteome study

David P. Herzog, Natarajan Perumal, Caroline Manicam, Giulia Treccani, Jens Nadig, Milena Rossmanith, Jan Engelmann, Tanja Jene, Annika Hasch, Michael A. van der Kooij, Klaus Lieb, Nils C. Gassen, Franz H. Grus, Marianne B. Müller

This study identifies HNK's mechanism of action by analyzing CSF proteome changes, showing its impact on glucocorticoid receptor signaling and potential upstream regulators.

Neurobiology of Stress · Sep 29, 2021Peer-reviewedNeuroscience

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

Niamh Mullins, Jooeun Kang, Adrián I. Campos, Jonathan R. I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey A. Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark J. Adams, Swapnil Awasthi, Michael J. Gandal, , DAVID L. BRAFF

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

Biological Psychiatry · Sep 8, 2021Peer-reviewedGenetic & Genomic Medicine

Cortical network mechanisms of response inhibition

Michael Schaum, Edoardo Pinzuti, Alexandra Sebastian, Klaus Lieb, Pascal Fries, Arian Mobascher, Patrick Jung, Michael Wibral, Oliver Tüscher

This study investigates the functional roles of rIFG and pre-SMA in response inhibition using MEG/fMRI, finding rIFG precedes pre-SMA activity and drives connectivity predicting stopping performance.

bioRxiv · Feb 9, 2020 · PreprintNeuroscience