Author

Elgin Henry Akin

Johns Hopkins UniversityORCID 0000-0001-8824-8809Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrew S PekosziD· 4 shared Anne P. WerneriD· 3 shared Amary FalliD· 2 shared Heba H. MostafaiD· 2 shared Jaiprasath SachithanandhamiD· 2 shared Katherine FenstermacheriD· 2 shared Matthew PinsleyiD· 2 shared Richard Eric RothmaniD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

Andrew S PekoszORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 29, 2026

Influenza A virus H5N1 genotypes B3.13 and D1.1 show temperature-dependent restriction of replication in primary human respiratory epithelial cell cultures derived from the upper and lower respiratory tract.

Anne P. Werner, Jaiprasath Sachithanandham, Elgin Henry Akin…·Andrew S Pekosz

This study compares the temperature-dependent replication of H5N1 genotypes B3.13 and D1.1 with H1N1pdm09 in human respiratory epithelial cells, finding differences in replication efficiency at different temperatures.

DOI 10.64898/2026.08.27.747488

humanexperimental assay

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MicrobiologymBioPeer-reviewedJun 22, 2026

Emergence of an Antigenically Drifted and Reassorted Influenza B Virus at the end of the 2024-25 Influenza Season

Elgin Henry Akin, David A. Villafuerte, Anne P. Werner…·Andrew S Pekosz

This study identifies an antigenically drifted and reassorted Influenza B virus, C.3.1/re, emerging late in the 2024-25 season, which is poorly neutralized by existing vaccines and may impact future vaccine strain selection.

3 citationstop 2%

humanproteomics

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MicrobiologyNaturePeer-reviewedApr 8, 2026

DNA damage drives antigen diversification through mosaic VSG formation in Trypanosoma brucei

Jaclyn E. Smith, Kevin J. Wang, Erika Kennedy…·Monica R. Mugnier

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

9 citationstop 1%

experimental assaygenetic perturbation / CRISPR

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ImmunologymBioPeer-reviewedOct 31, 2025

Low levels of H5N1 HA and NA antibodies in the human population are boosted by seasonal A/H1N1 infection but not by A/H3N2 infection or influenza vaccination

Anne P. Werner, Cosette G. Schneider, Elgin Henry Akin…·Andrew S Pekosz

The paper measures antibody responses to bovine A/H5N1 HA and NA in vaccinated and infected individuals, finding that A/H1N1 infection boosts neutralizing antibodies but vaccination and A/H3N2 infection do not.

14 citationstop 1%

humanproteomics

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MicrobiologyVirusesPeer-reviewedSep 9, 2024

SARS-CoV-2 variants from long-term, persistently infected immunocompromised patients have altered syncytia formation, temperature-dependent replication, and serum neutralizing antibody escape

Camille Wouters, Jaiprasath Sachithanandham, Elgin Akin…·Andrew S Pekosz

The paper studies SARS-CoV-2 variants from immunocompromised patients, finding altered syncytia formation, temperature-dependent replication, and antibody escape in some isolates.

2 citations

humanbulk RNA-seq

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