Ritika Giri

The paper analyzes single-cell Senseless protein dynamics in Drosophila to show metastable states during sensory organ fate transition.

The paper shows that stochastic gene expression, specifically in senseless protein output, is critical for developmental self-organization in Drosophila, with genomic location and microRNA regulation influencing noise and sensory pattern formation.

The paper shows that layered weak repression synchronizes developmental gene regulation with cellular metabolism, and that reducing metabolism can compensate for loss of repressors.