Author

Richard L. Mackman

Gilead Sciences (United States)ORCID 0000-0001-8861-7205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:non-human primate· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Arya VijjapurapuiD· 2 shared Dustin S. SiegeliD· 2 shared Jared PittsiD· 2 shared Jason K. PerryiD· 2 shared John P. BilelloiD· 2 shared Meghan S. VermillioniD· 2 shared Nicholas C. RiolaiD· 2 shared Raju SubramanianiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Arya VijjapurapuORCID

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2 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedJul 11, 2025

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

Jared Pitts, J. Lizbeth Reyes Zamora, Savrina Manhas…·John P. Bilello

This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.

7 citationstop 4%

non-human primateexperimental assay

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BiochemistryJournal of Medicinal ChemistryPeer-reviewedJul 17, 2024

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

Dustin S. Siegel, Hon C. Hui, Jared Pitts…·Richard L. Mackman

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

17 citationstop 4%

non-human primateexperimental assay

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