Author

Dustin S. Siegel

Gilead Sciences (United States)ORCID 0009-0008-1365-0287Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:non-human primate· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jared PittsiD· 3 shared Jason K. PerryiD· 3 shared John P. BilelloiD· 3 shared Arya VijjapurapuiD· 2 shared Joy Y. FengiD· 2 shared Meghan S. VermillioniD· 2 shared Nicholas C. RiolaiD· 2 shared Raju SubramanianiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Jared PittsORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedJul 11, 2025

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

Jared Pitts, J. Lizbeth Reyes Zamora, Savrina Manhas…·John P. Bilello

This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.

7 citationstop 4%

non-human primateexperimental assay

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BiochemistryJournal of Medicinal ChemistryPeer-reviewedJul 17, 2024

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

Dustin S. Siegel, Hon C. Hui, Jared Pitts…·Richard L. Mackman

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

17 citationstop 4%

non-human primateexperimental assay

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BiochemistryJournal of Biological ChemistryPeer-reviewedJun 28, 2024

Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Calvin J. Gordon, Simon M. Walker, Egor P. Tchesnokov…·Matthias Götte

This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.

15 citationstop 5%

humanbiophysical modeling

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