Author
Gilead Sciences (United States)ORCID 0000-0001-5492-0652Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Jason K. Perry, Samuel Itskanov, John P. Bilello, E.B. Lansdon
The paper constructs a structural model of coronavirus DMV pore formation and its role in polyprotein processing and replication.
Jared Pitts, J. Lizbeth Reyes Zamora, Savrina Manhas…·John P. Bilello
This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.
Dustin S. Siegel, Hon C. Hui, Jared Pitts…·Richard L. Mackman
This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.
Calvin J. Gordon, Simon M. Walker, Egor P. Tchesnokov…·Matthias Götte
This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.
Jason K. Perry, Todd C. Appleby, John P. Bilello…·Elizabeth A. Campbell
The paper constructs an atomistic model of the SARS-CoV-2 replication-transcription complex, revealing its hexameric structure centered on nsp15 and detailing interactions between viral proteins.
Ross Martin, Jiani Li, Aiyappa Parvangada…·Evguenia S. Svarovskaia
The paper analyzes genetic diversity in SARS-CoV-2 RNA replication complex across global isolates and variants, finding minimal pre-existing resistance to remdesivir.