Sanna Madan

This paper introduces LogiCAR designer, a computational method using single-cell transcriptomics to identify logic-gated antigen combinations for CAR therapy, showing improved efficacy and safety compared to existing approaches.

IMMClock predicts immune age of T cells and NK cells using gene expression, showing immune aging is more linked to cellular aging than differentiation and is accelerated in diseases.

The paper analyzes pan-cancer single-cell transcriptomes to evaluate and identify new CAR targets for head and neck cancer, finding five promising targets with superior selectivity and safety.