Author

Andrew Martinez

Cedars-Sinai Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Simon KnottiD· 3 shared Nathan Ing· 2 shared Aagam S. ShahiD· 1 shared Alejandro A. SchäfferiD· 1 shared Alexandra R. HarrisiD· 1 shared Alice Y. HoiD· 1 shared Aravind SrinivasaniD· 1 shared Armando E. GiulianoiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenomics

Simon KnottORCID

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Author profile →

3 papers

Recent·Most cited

Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy

Sanna Madan, Tiangen Chang, Alexandra R. Harris, Huaitian Liu, Andrew Martinez, Saugato Rahman Dhruba, Binbin Wang, Padma Sheila Rajagopal, Sanju Sinha, Aravind Srinivasan, Simon Knott, Shahin Sayed, Francis Makokha, Chi‐Ping Day, Gretchen L. Gierach, , Eytan Ruppin

This paper introduces LogiCAR designer, a computational method using single-cell transcriptomics to identify logic-gated antigen combinations for CAR therapy, showing improved efficacy and safety compared to existing approaches.

bioRxiv · Mar 19, 2025 · PreprintBioinformatics

Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structures

Richard H. Mebane, Teia Noel, Nathan Ing, Kenneth H. Gouin, Aagam S. Shah, David Zitser, Andrew Martinez, Gaorav P. Gupta, Alice Y. Ho, Heather L. McArthur, Stephen Lawrence Shiao, Simon Knott

The paper uses single RNA molecule resolution imaging to analyze immunotherapy response in triple negative breast tumors with tertiary lymphoid structures, identifying two tumor types based on immune infiltration and their differential responses to pembrolizumab and radiation therapy.

bioRxiv · Mar 19, 2024 · PreprintGenomics

The molecular consequences of androgen activity in the human breast

Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, , Simon Knott

This study investigates the molecular effects of androgen in the human breast using single-cell transcriptome, chromatin, and spatial profiling of transgender men undergoing androgen therapy, revealing changes in gene expression, immune populations, vasculature, and metabolism.

Cell Genomics · Mar 1, 2023Peer-reviewedGenomics