BioinformaticsbioRxivPreprint
Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy
Sanna Madan, Tiangen Chang, Alexandra R. Harris…·Eytan Ruppin
This paper introduces LogiCAR designer, a computational method using single-cell transcriptomics to identify logic-gated antigen combinations for CAR therapy, showing improved efficacy and safety compared to existing approaches.