Scott A. Horowitz

This study introduces CHAP-SEQ to analyze how protein- and RNA-based chaperones assist in protein folding, revealing distinct mechanisms for each type.

This study shows that G-quadruplex sequences influence tau oligomerization and fibril morphology in human hippocampal aggregates.

The paper describes how Foldit players improved protein structure models in the PDB, enhancing the output of the PDB-REDO pipeline.

This study shows that RNA G-quadruplexes influence TDP43 condensation and toxicity in different cell types, suggesting targeting these structures could be a new approach for treating protein misfolding diseases.

This study quantitatively characterizes the thermodynamics of RNA nanostructure self-assembly, showing sensitivity to environmental conditions and distinct melting temperatures for tertiary and secondary structures.

This study finds increased RNA G-quadruplex accumulation in aging and Alzheimer's disease hippocampus, linking it to tau aggregation and APOE genotype.

The paper shows that G-quadruplexes can catalyze protein folding without ATP, reshaping the energy landscape and suggesting a broader capacity for protein folding in cells.