Olivier Hyrien

The paper develops a mechanistic model of vaccine-induced humoral responses, showing class-specific activation and competition among B cells, with stronger competition within classes.

The paper develops a method to create high-resolution single-molecule replication maps of the human genome using multipulse BrdU labelling and ForkML.

This paper introduces a Bayesian model for DNA replication that infers origin timing and activation delays using RFD data, revealing 150 origins with significant delays in yeast.

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

The paper investigates DNA replication dynamics in Xenopus, identifying two replication modes with distinct fork speeds and origin firing rates, and shows Plk1's role in coordinating these processes.

Nanotiming provides high-resolution telomere-to-telomere replication timing profiles using nanopore sequencing, validated in yeast with cost and simplicity advantages.

FORK-seq maps DNA replication at single-molecule resolution in yeast, revealing previously missed initiation and termination events.

The paper uses nanopore sequencing and a neural network to identify BrdU-labelled DNA tracts in yeast during replication, showing they align with early-firing origins.

This paper develops a high-throughput method to map DNA replication at the single-molecule level using an optical mapping system.