Laurent Lacroix

G4All is a curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with controls, enabling comparative analysis and predictive model development.

The paper develops a method to create high-resolution single-molecule replication maps of the human genome using multipulse BrdU labelling and ForkML.

This paper introduces a Bayesian model for DNA replication that infers origin timing and activation delays using RFD data, revealing 150 origins with significant delays in yeast.

Nanotiming provides high-resolution telomere-to-telomere replication timing profiles using nanopore sequencing, validated in yeast with cost and simplicity advantages.

FORK-seq maps DNA replication at single-molecule resolution in yeast, revealing previously missed initiation and termination events.