Aleksei Agapov

Loss of restriction-modification methyltransferases drives persistence to fluoroquinolones in Pseudomonas aeruginosa

This study shows that loss of type I restriction-modification methyltransferases in Pseudomonas aeruginosa increases fluoroquinolone persistence through enhanced SOS response and slower growth.

Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system

The paper defines the mechanism of the MANTIS defence system in Pseudomonas aeruginosa, showing how dual ATPases couple self-modification to non-self restriction through adenine hemimethylation and cleavage.

Engineering the Pseudomonas aeruginosa virus-isolation host viPAO1 reveals how host genetic barriers shape recoverable phage diversity

The paper shows that removing genetic barriers from Pseudomonas aeruginosa hosts increases the diversity of recoverable phages, leading to the isolation of 69 new phages from clinical isolates.

Defence systems drive accessory genome interactions in Pseudomonas aeruginosa.

The paper analyzes defence system interactions in Pseudomonas aeruginosa genomes to understand their role in shaping accessory genome dynamics and ecological patterns.

Bacterial Argonaute nucleases reveal different modes of DNA targeting in vitro and in vivo

This study investigates the DNA targeting mechanisms of five bacterial Argonaute proteins in vitro and in vivo, revealing their ability to cleave DNA and defend against bacteriophages.

Bacterial Argonaute proteins aid cell division in the presence of topoisomerase inhibitors in Escherichia coli

The paper shows that bacterial Argonaute proteins assist in cell division in E. coli under topoisomerase inhibitor stress by processing DNA replication termination sites.