Todd E. Thiele

Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis

This study investigates the role of CRFR1 in the lateral hypothalamus during chronic binge drinking, finding that posterior LH CRFR1 knockdown increases alcohol consumption while also increasing anxiety and reducing sucrose preference.

Inhibiting CRF Projections from the Central Amygdala to Lateral Hypothalamus and Amygdala Deletion of CRF Alters Binge-Like Ethanol Drinking in a Sex-Dependent Manner

This study shows that inhibiting CRF projections from the central amygdala to the lateral hypothalamus reduces binge-like ethanol drinking in male, but not female, mice.

Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice.

This study examines gene expression changes in the CeA of male and female mice during acute and protracted abstinence from binge drinking, revealing sex-specific differences in gene regulation.

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior

This study identifies a sex-dependent glutamatergic circuit from the paraventricular thalamus to BNST CRF neurons that modulates binge drinking and avoidance behavior.