Jeffrey F. DiBerto

A suite of engineered mice for interrogating psychedelic drug actions

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

A proximity proteomics pipeline with improved reproducibility and throughput

This paper introduces a scalable proximity proteomics pipeline that improves reproducibility and throughput in biotinylation-based spatial proteomics.

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework

This study uses a generative deep learning framework to design new KOR antagonists, which are prioritized for synthesis and validated through experimental assays.

Serotonin Modulates an Inhibitory Input to the Central Amygdala from the Ventral Periaqueductal Gray

This study identifies a serotonin-modulated GABAergic pathway from the vPAG to the CeA that enhances fear learning through 5HT2C receptor activation.

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior

This study identifies a sex-dependent glutamatergic circuit from the paraventricular thalamus to BNST CRF neurons that modulates binge drinking and avoidance behavior.

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

This study shows that neurotensin neurons in the central amygdala of mice influence ethanol and sweet fluid consumption through projections to the parabrachial nucleus.