Sarah E. Newey

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

The paper shows that inhibitory input to pyramidal neurons in layer 2/3 depends on their embryonic progenitor type, shaping local inhibitory subnetworks.

The paper shows that cortical neurons integrate higher-order thalamic inputs based on their lineage, with apical intermediate progenitor-derived neurons exhibiting specific response properties and dependency on Lhx2.

The paper shows that intraneuronal chloride levels increase with wakefulness, reducing synaptic inhibition and affecting cortical function, and that targeting chloride can restore performance in tired states.

The paper investigates the cellular mechanisms of benzodiazepine resistance in status epilepticus, finding that persistent high intraneuronal chloride levels contribute to reduced GABAA receptor function and enhanced epileptiform activity.

The paper investigates how embryonic progenitor pools shape excitatory cortical circuits through precise synaptic connections.