Joseph V. Raimondo

This study shows human cortical neurons mature slowly into adulthood, unlike mice, and develops a model to simulate this process across species.

The paper investigates how cestode larvae affect neuronal activity by exciting host neuronal circuits through glutamatergic signaling, leading to seizure-like events in vitro.

This study uses a spiking neural network model with chloride dynamics to show that benzodiazepine efficacy in status epilepticus depends on GABAAR reversal potential and pyramidal cell chloride extrusion.

This study analyzes human dendritic spine morphology and density using a unique dataset and deep learning, revealing sex and tissue-specific differences and changes over time in culture.

This study uses snRNA-seq and spatial transcriptomics to create a pediatric and adult brain cell atlas, identifying cell type-specific gene expression changes during human brain maturation.

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

The paper investigates GABAAR signaling in awake versus anesthetized mouse cortex, finding that awake networks exhibit shunting inhibition due to depolarized GABAAR equilibrium potentials.

The paper uses computational models to determine the optimal placement of inhibitory synapses to minimize dendritic excitability by analyzing chloride dynamics and inhibitory accumulation.

The paper investigates the effects of peripheral Taenia crassiceps infection on the central nervous system in mice, finding increased immunoglobulins and blood-brain barrier permeability without proinflammatory cytokine changes.

This study generates iPSCs from SCA7 patients and shows molecular and electrophysiological abnormalities in derived neurons and photoreceptors.

This study profiles acetylcholinesterase activity in Taenia solium and Taenia crassiceps larvae, showing differences in activity levels and localization, and demonstrates their ability to modulate neuronal responses to acetylcholine.

The paper develops computational models to show how chloride dynamics affect neuronal input-output functions through changes in dendritic inhibition.

The paper compares two in vitro models of epileptic seizures, finding differences in glutamatergic involvement and seizure-like event characteristics.

The paper investigates the cellular mechanisms of benzodiazepine resistance in status epilepticus, finding that persistent high intraneuronal chloride levels contribute to reduced GABAA receptor function and enhanced epileptiform activity.

The paper uses biophysical models to show that cation-chloride cotransporters, not impermeant anions, primarily modulate chloride driving force in neurons.

Openspritzer is an open hardware system for delivering picolitre volumes with performance comparable to commercial systems, demonstrated in neurobiology applications.