Colin J. Akerman

This paper introduces a model where neurons adjust synaptic strengths to minimize somato-dendritic mismatch, enabling network learning and reproducing experimental observations of plasticity.

The paper shows that manipulating cortical activity during sleep deprivation prevents ER stress responses while increasing sleep pressure markers.

The paper shows that sleep deprivation causes depolarizing GABAAR signaling and spike threshold adaptation in cortical neurons, stabilizing network activity despite increased firing rates.

This study investigates how global and local cortical activity affects sleep regulation using chemogenetic manipulations of Rbp4-Cre+ neurons.

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

The paper shows that inhibitory input to pyramidal neurons in layer 2/3 depends on their embryonic progenitor type, shaping local inhibitory subnetworks.

Somnotate is a probabilistic classifier that improves sleep stage annotation in mice by identifying intermediate states and transitions, outperforming human experts.

The paper investigates GABAAR signaling in awake versus anesthetized mouse cortex, finding that awake networks exhibit shunting inhibition due to depolarized GABAAR equilibrium potentials.

This study shows that diurnal changes in GABAA receptor equilibrium potential modulate glutamatergic long-term potentiation in mouse cortical neurons.

The paper uses an optogenetic approach to measure dynamic and cell-type-specific chloride equilibrium potentials in rodent neurons.

This study shows that clozapine-N-oxide and compound 21 affect sleep in mice, suggesting that chemogenetic actuators may have off-target effects beyond DREADD receptor activation.

The paper develops biologically plausible variants of RBMs with sparse and asymmetric connectivity and benchmarks their performance on MNIST.

The paper shows that cortical neurons integrate higher-order thalamic inputs based on their lineage, with apical intermediate progenitor-derived neurons exhibiting specific response properties and dependency on Lhx2.

This study shows that silencing specific cortical neurons in mice increases wakefulness and reduces sleep rebound after deprivation, highlighting the cortex's role in sleep regulation.

The paper shows that intraneuronal chloride levels increase with wakefulness, reducing synaptic inhibition and affecting cortical function, and that targeting chloride can restore performance in tired states.

The paper develops computational models to show how chloride dynamics affect neuronal input-output functions through changes in dendritic inhibition.

The paper investigates the cellular mechanisms of benzodiazepine resistance in status epilepticus, finding that persistent high intraneuronal chloride levels contribute to reduced GABAA receptor function and enhanced epileptiform activity.

The paper uses biophysical models to show that cation-chloride cotransporters, not impermeant anions, primarily modulate chloride driving force in neurons.

This study uses chemicogenetic techniques to selectively enhance inhibitory interneurons in the hippocampus, finding that PV interneurons most effectively suppress seizure activity in vitro and in vivo.

The paper investigates how embryonic progenitor pools shape excitatory cortical circuits through precise synaptic connections.