Hannah Alfonsa

Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

This study shows that silencing layer 6b neurons in mice alters theta frequency and EEG power during wake and sleep, and reduces orexin-induced wakefulness.

Opposing intrinsic and synaptic plasticity mechanisms stabilize altered cortical networks during sleep deprivation

The paper shows that sleep deprivation causes depolarizing GABAAR signaling and spike threshold adaptation in cortical neurons, stabilizing network activity despite increased firing rates.

Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions

Somnotate is a probabilistic classifier that improves sleep stage annotation in mice by identifying intermediate states and transitions, outperforming human experts.

Metaplasticity of cortical glutamatergic LTP by diurnal intracellular chloride dynamics

This study shows that diurnal changes in GABAA receptor equilibrium potential modulate glutamatergic long-term potentiation in mouse cortical neurons.

Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice

This study shows that clozapine-N-oxide and compound 21 affect sleep in mice, suggesting that chemogenetic actuators may have off-target effects beyond DREADD receptor activation.

Intraneuronal chloride levels encode tiredness in cortex

The paper shows that intraneuronal chloride levels increase with wakefulness, reducing synaptic inhibition and affecting cortical function, and that targeting chloride can restore performance in tired states.