Richard Joseph Burman

The paper shows that sleep deprivation causes depolarizing GABAAR signaling and spike threshold adaptation in cortical neurons, stabilizing network activity despite increased firing rates.

This study uses a spiking neural network model with chloride dynamics to show that benzodiazepine efficacy in status epilepticus depends on GABAAR reversal potential and pyramidal cell chloride extrusion.

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

The paper shows that inhibitory input to pyramidal neurons in layer 2/3 depends on their embryonic progenitor type, shaping local inhibitory subnetworks.

The paper investigates GABAAR signaling in awake versus anesthetized mouse cortex, finding that awake networks exhibit shunting inhibition due to depolarized GABAAR equilibrium potentials.

The paper uses an optogenetic approach to measure dynamic and cell-type-specific chloride equilibrium potentials in rodent neurons.

The paper identifies genetic variants in South African children with developmental and epileptic encephalopathies and proposes a 'Think-Genetics' strategy for early genetic diagnosis in resource-limited settings.

This study generates iPSCs from SCA7 patients and shows molecular and electrophysiological abnormalities in derived neurons and photoreceptors.

The paper compares two in vitro models of epileptic seizures, finding differences in glutamatergic involvement and seizure-like event characteristics.

The paper investigates the cellular mechanisms of benzodiazepine resistance in status epilepticus, finding that persistent high intraneuronal chloride levels contribute to reduced GABAA receptor function and enhanced epileptiform activity.

The paper uses biophysical models to show that cation-chloride cotransporters, not impermeant anions, primarily modulate chloride driving force in neurons.

Openspritzer is an open hardware system for delivering picolitre volumes with performance comparable to commercial systems, demonstrated in neurobiology applications.