Ian Brettell

The paper develops a behavioral assay and uses a Hidden Markov Model to analyze bold-shy behaviors in medaka fish, identifying direct and social genetic effects on behavior.

This study shows that spatial and temporal control of axis segmentation in medaka fish are dissociable modules, identified through devQTL mapping and CRISPR validation.

The paper introduces the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel, a vertebrate genetic resource for genotype-to-phenotype studies, enabling controlled experiments on complex traits.

The paper analyzes genomic and epigenomic variation in the MIKK panel using long-read sequencing and pan-genome graphs, revealing novel structural variants and methylation patterns.