Sara Palma-Tortosa

Ex vivo astrocyte-to-oligodendrocyte conversion in human adult cortical tissue using transcription factor overexpression

This study demonstrates that overexpressing OLIG2 and SOX10 in human astrocytes converts them into oligodendrocytes ex vivo, preserving brain architecture and showing potential for myelin repair in MS.

Longitudinal tractography monitors cortical stroke-induced thalamocortical degeneration and neuroprotection by human iPSC-derived neurons

This study uses longitudinal tractography to track thalamocortical degeneration after cortical stroke and shows that hiPSC-derived neuronal transplantation preserves thalamic connectivity and reduces atrophy.

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.

Human monocyte subtype expression of neuroinflammation and -regeneration-related genes is linked to age and sex

The paper examines how age and sex influence gene expression in human monocyte subtypes related to neuroinflammation and regeneration, identifying age- and sex-dependent gene changes.

Human cortical neurons rapidly generated by direct ES cell programming integrate into stroke-injured rat cortex

This study generates human cortical neurons from hES cells via NGN2 overexpression and shows their integration into stroke-injured rat brains.

Oligodendrocytes in human iPS cell-derived cortical grafts remyelinate adult rat and human cortical neurons

This study shows human iPS cell-derived oligodendrocytes can remyelinate adult rat and human cortical neurons in vitro and in vivo.