Guillermina Lozano

Trp53 heterozygosity defines novel states impacting tumor plasticity and progression in Kras-initiated non-small cell lung cancer

This study shows that TP53 heterozygosity in Kras-mutant lung cancer affects tumor plasticity and progression, with distinct genomic and survival outcomes compared to complete TP53 loss.

Multi-omics analysis identifies intrinsic Trp53 driven metastatic breast cancer subtypes.

The paper identifies three intrinsic metastatic breast cancer subtypes driven by Trp53 mutations through multi-omics analysis, revealing distinct transcriptomic and genomic features.

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.