Author
University of UtahORCID 0009-0008-3683-0176Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Mona Foth, Wontak Kim, Kayla T. O’Toole…·Martin McMahon
This study identifies RAS(ON) inhibitors effective against NRAS-mutated melanoma and reveals resistance mechanisms through Ppia and Map2k1 mutations.
Kayla T. O’Toole, Adamaris Martinez, Brandon Murphy…·Martin McMahon
The paper identifies a novel interaction between BRAFV600E and TP53 in melanoma, suggesting that BRAFV600E inactivates TP53, explaining the rarity of TP53 alterations in this cancer type.
Phaedra C. Ghazi, Kayla T. O’Toole, Sanjana Srinivas Boggaram…·Martin McMahon
This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.