Joanne L. Dunster

This study models platelet calcium signaling using recurrent neural networks and partial least squares to predict and interpret calcium response patterns under various agonist conditions.

This study shows a direct link between platelet reactivity and neurovascular function in older adults, independent of vascular reactivity, suggesting a novel mechanism in early dementia pathophysiology.

The paper develops a computational model of CLEC-2 signaling and validates its predictions experimentally, revealing temperature-dependent activation and lipid raft involvement.