Robin J.M. Franklin

The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells

The paper identifies BCL11A as a transcription factor that restores differentiation potential in aged oligodendrocyte progenitor cells through computational analysis and experimental validation.

Single-nucleoid imaging in whole cells defines the dynamics of the mtDNA life cycle

The paper uses advanced imaging techniques to study mtDNA dynamics in quiescent human cells, revealing rapid replication and degradation rates and spatial organization of mtDNA.

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter

This study develops an MRI-based method to track oligodendrocyte progenitor cell differentiation during remyelination in vivo using a gene reporter system.

Extrinsic cues unlock cross-germ layer differentiation potential of CNS stem cells during regeneration

The paper identifies integrin and BMP signaling pathways that drive OPC-to-SC differentiation in CNS regeneration using single-cell genomics.

Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination

The paper identifies age-related dysregulation of transcription networks in oligodendrocyte differentiation using single-nucleus RNA and ATAC sequencing in mice, with parallels in MS lesions.

Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

A retroviral origin of vertebrate myelin

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

Circulating Platelets Modulate Oligodendrocyte Progenitor Cell Differentiation During Remyelination

This study shows platelets modulate OPC differentiation during remyelination, with transient exposure promoting and sustained exposure inhibiting differentiation in a mouse model of MS.

Combination-Based Drug Screening for Induced Oligodendrocyte Differentiation Enables Mechanistic Insight and Identifies Optimal Drug Pairs for Remyelination

The paper identifies drug pairs for remyelination using combination screening and provides mechanistic insights into their efficacy and toxicity.

Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

This study shows that ageing impairs regulatory T cells' ability to promote remyelination by reducing their capacity to drive oligodendrocyte differentiation and myelination.

SARM1 detection in oligodendrocytes but not Schwann cells though sarm1/Sarm1 deletion does not perturb CNS nor PNS myelination in zebrafish and mice.

The paper shows SARM1 is present in oligodendrocytes but not Schwann cells, and its deletion does not affect myelination in zebrafish or mice.

The role of complex IV activity in the axonal response of mitochondria to demyelination in experimental disease models of multiple sclerosis

The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.

Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

A map of transcriptional heterogeneity and regulatory variation in human microglia

The paper profiles gene expression in human microglia from 141 patients, identifies population shifts in acute brain injury, maps eQTLs, and fine-maps Alzheimer's risk variants using hIPSC-derived macrophages.

The proteome of remyelination is different from that of developmental myelination

The paper compares the proteome of remyelination and developmental myelination in mice, finding distinct protein compositions and identifying potential therapeutic targets.

The neuroprotective effects of Sonic hedgehog pathway agonist SAG in a rat model of neonatal stroke

This study shows that a single dose of SAG, a Shh pathway agonist, reduces brain injury and improves cognitive outcomes in a rat model of neonatal stroke.

Genome-wide meta-analysis, fine-mapping, and integrative prioritization identify new Alzheimer's disease risk genes

Meta-analysing UK Biobank family-history GWAS with diagnosed-AD GWAS yields 37 loci, four novel (NCK2, TSPAN14, SPRED2, CCDC6); fine-mapping, colocalisation and network scoring prioritize causal genes.

Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelination

This study shows that OPC proliferation is required for differentiation during CNS remyelination, revealing a link between proliferation and differentiation in OPCs.

Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.

The microbiota regulates inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

This study shows that microbiota modulates inflammatory responses during CNS demyelination but has little effect on remyelination in mice.

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.