Sarah M. Knox

Rapid evolution of mouse saliva through regulatory rewiring and gene expansions

This study identifies rapid evolution of mouse saliva through regulatory rewiring and gene expansions, highlighting lineage-specific genes and sex-biased expression.

Rebuilding the autoimmune-damaged corneal stroma through topical lubrication

This study shows that topical lubrication can regenerate the damaged corneal stroma in a mouse model by converting inflammatory keratocytes into reparative cells.

Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling

This study shows that muscarinic agonists can restore non-healing salivary glands by reactivating endogenous regeneration and mitochondrial function through cholinergic-calcium signaling.

Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic Development

This study maps human fetal pancreatic development using scRNA-Seq and snATAC-Seq, identifying novel cell types and regulatory mechanisms, and highlights gene FEV's role in endocrine differentiation.

Functional specialization of human salivary glands and origins of proteins intrinsic to human saliva

The paper identifies the origins of salivary proteins and reveals gene repertoires specific to fetal and adult salivary glands, showing functional diversity is driven by transcriptional regulators.

Development of mouse and human cochlea at single cell resolution

This study maps mouse and human cochlea development using single-cell RNA-sequencing and a new clustering algorithm, identifying new cell types and gene associations related to hearing loss.