Ieva Drulyte

The paper determines the structure of norovirus NS3 and proposes it functions as an RNA translocase.

This study identifies spike and host glycan determinants of HKU1 airway tropism by showing preferential binding to 9-O-acetylated 2,8-linked disialosides and structural insights into ligand recognition.

This paper develops a method to discover PANX1 modulators using DNA-encoded library screening with stabilized membrane protein nanoparticles and validates hits through biophysical and electrophysiological assays.

This paper determines the structure of the EEHV1A gH/gL/gO complex and shows it functions as the receptor-binding complex for EEHV1A.

This paper evaluates the efficacy of multimeric bicyclic peptides as antiviral agents in preclinical SARS-CoV-2 models, showing significant reduction in viral burden across multiple therapeutic settings.

This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.

This paper presents a computational pipeline for designing therapeutic antibodies using AI and physics-based methods, showing improved binding and developability across SARS-CoV-2 variants.