Author

Yaw Shin Ooi

Duke-NUS Medical SchoolORCID 0000-0001-9014-1365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aaron D. GitleriD· 1 shared Akanksha RawatiD· 1 shared Alan Chen-Yu Hsu· 1 shared Alex G. JohnsoniD· 1 shared Camille Trupin· 1 shared Christopher M. RichardsiD· 1 shared Christopher P. LapointeiD· 1 shared Clara Shi Ya NgiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Aaron D. GitlerORCID

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2 papers

Recent·Most cited

An integration-free CRISPR platform for genetic dissection of respiratory virus host dependencies in human nasal epithelium

Sophie Wilhelmina van Leur, Julie T. S. Chu, Xuesheng Wu, Akanksha Rawat, Nicholas Kim‐Wah Yeo, Trena Wan Xuan Lee, Marcus G. Mah, Yung-Jiun Chen, Clara Shi Ya Ng, Camille Trupin, Alan Chen-Yu Hsu, Gavin J. D. Smith, Yaw Shin Ooi, Mart Matthias Lamers

The paper develops an integration-free CRISPR platform to study host dependencies of respiratory viruses in human nasal epithelium, showing ACE2 and TMPRSS2 are critical for SARS-CoV-2 and hCoV-NL63 infection.

bioRxiv · Oct 8, 2026 · PreprintMicrobiology

A memory of RPS25 loss drives resistance phenotypes

Alex G. Johnson, Ryan A. Flynn, Christopher P. Lapointe, Yaw Shin Ooi, Michael L. Zhao, Christopher M. Richards, Wenjie Qiao, Shizuka B. Yamada, Julien Couthouis, Aaron D. Gitler, Jan E. Carette, Joseph Daniel Puglisi

The paper investigates the phenotypic consequences of RPS25 and RACK1 loss in human cells, finding that RPS25 knockout leads to irreversible resistance traits and gene expression rewiring.

bioRxiv · Mar 31, 2020 · PreprintMolecular Biology