Alex G. Johnson

Pyroptolysins are versatile, sterol-sensing bacterial toxins

This study identifies pyroptolysins as bacterial toxins with a gasdermin fold that can induce cell death from inside and outside cells, showing activity on low sterol membranes.

Structure and Mechanism of a Two-component Lanthipeptide Toxin

The paper presents the first high-resolution structure of two interacting lanthipeptides and shows how they disrupt cell membranes.

A memory of RPS25 loss drives resistance phenotypes

The paper investigates the phenotypic consequences of RPS25 and RACK1 loss in human cells, finding that RPS25 knockout leads to irreversible resistance traits and gene expression rewiring.

Ribosomal protein RACK1 facilitates efficient translation of poliovirus and other viral IRESs

This study shows that RACK1 enhances poliovirus translation and infection by facilitating viral IRES-mediated translation, with reduced RACK1 leading to smaller viral plaques and delayed host translational shut-off.

Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans

The paper identifies N-glycan modifications on mammalian Y RNAs, showing RNA can be a scaffold for glycosylation in the secretory pathway.