Author

Gemma L. Fryatt

Southampton General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Diego Gómez‐NicolaiD· 3 shared Andrea Domenico RiveraiD· 2 shared Arthur Morgan ButtiD· 2 shared Irene Chacon De La RochaiD· 2 shared Olivier RaineteauiD· 2 shared Adrián Olmos‐Alonso· 1 shared Alexei VerkhratskyiD· 1 shared Daniel Thomas· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Diego Gómez‐NicolaORCID

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3 papers

Recent·Most cited

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Abeta pathology

Yanling Hu, Gemma L. Fryatt, Mohammadmersad Ghorbani, Juliane Obst, David A. Menassa, María Martín‐Estebané, Tim A.O. Muntslag, Adrián Olmos‐Alonso, Monica Guerrero‐Carrasco, Daniel Thomas, Mark Steven Cragg, Diego Gómez‐Nicola

This study shows that excessive microglial proliferation in Alzheimer's disease leads to replicative senescence and disease-associated microglia, contributing to Aβ pathology.

Cell Reports · Jun 1, 2021Peer-reviewedNeuroscience

Accelerated dystrophy and decay of oligodendrocyte precursor cells in the APP/PS1 model of Alzheimer's-like pathology

Irene Chacon De La Rocha, Gemma L. Fryatt, Andrea Domenico Rivera, Alexei Verkhratsky, Olivier Raineteau, Diego Gómez‐Nicola, Arthur Morgan Butt

The paper examines age-related changes in oligodendrocyte precursor cells (OPCs) in APP/PS1 mice, showing accelerated dystrophy and decay compared to non-transgenic controls.

Frontiers in Cellular Neuroscience · Dec 2, 2020Peer-reviewedNeuroscience

Synaptic silencing affects the density and complexity of oligodendrocyte precursor cells in the adult mouse hippocampus

Irene Chacon De La Rocha, Gemma L. Fryatt, Andrea Domenico Rivera, Laura Restani, Matteo Caleo, Olivier Raineteau, Diego Gómez‐Nicola, Arthur Morgan Butt

This study shows that synaptic silencing reduces oligodendrocyte precursor cell density and complexity in adult mouse hippocampus.

bioRxiv · Sep 23, 2020 · PreprintNeuroscience