Dale Michael Ando

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

This paper introduces a method for improving phenotypic measurements in high-content imaging screens by using a pre-trained deep metric network to classify drugs based on molecular mechanisms without requiring additional labeled data.