Author

William C. Johnson

Tufts UniversityORCID 0000-0003-0088-0063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Bree B. AldridgeiD· 2 shared Shumin TaniD· 2 shared Trever C. SmithiD· 2 shared A. Paul Alivisatos· 1 shared Artem SokoloviD· 1 shared Dale Michael AndoiD· 1 shared Dirk SchnappingeriD· 1 shared Eun Seon ChungiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMicrobiology

Bree B. AldridgeORCID

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2 papers

Recent·Most cited

MicrobiologyCell SystemsPeer-reviewedJul 29, 2025

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

William C. Johnson, A. Paul Alivisatos, Trever C. Smith…·Bree B. Aldridge

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

5 citations

spatial transcriptomicsimaging

𝕏 PostBluesky

MicrobiologybioRxivPreprintJul 14, 2025

Increased proportion of growth-arrested bacilli in acidic pH adaptation promotes Mycobacterium tuberculosis treatment survival

Eun Seon Chung, William C. Johnson, Maliwan Kamkaew…·Bree B. Aldridge

This study shows that Mycobacterium tuberculosis adapts to acidic conditions by increasing growth-arrested cells, which enhance drug tolerance and survival.

DOI 10.1101/2025.07.14.664820

experimental assayhost-pathogen & immune response

𝕏 PostBluesky