Ritchie Ho

This study develops three protocols to generate human iPSC-derived motor neurons with defined hindbrain, cervical, and lumbar identities, showing graded rostrocaudal specification and region-specific features.

This study creates a lifespan snRNA-seq atlas of mouse spinal cord, revealing how aging and SOD1-G93A ALS interact regionally and cell-type specifically.

This study examines sex-dependent and anatomic differences in motor function decline in SOD1G93A mice, finding males show earlier and less localized onset, and distinct decline rates between sexes.

This study identifies FGF21 as a biomarker in ALS associated with slower disease progression and protective effects against stress-induced cytotoxicity.

The paper generates and compares single-cell atlases of human neonatal and adult intervertebral discs to identify cellular heterogeneity, sub-populations, and developmental trajectories.

The paper uses single-cell RNA-seq to identify early ALS signatures in iPSC-derived motor neurons across multiple models and platforms.