João Bettencourt Relvas

This study identifies ARHGAP8 as a novel synaptic protein involved in excitatory synapse morphology and function, with implications for neurodevelopmental and psychiatric disorders.

This paper identifies KIF4A as a dual regulator of axonal regeneration in adult nervous systems, functioning in neurons and proliferative Schwann cells during injury.

This study identifies RhoA's role in regulating Schwann cell myelination by controlling cytoskeleton-membrane interactions and biomechanical responses.

This study examines how social instability stress during adolescence affects prefrontal cortex proteomics in rats, revealing sex- and age-dependent molecular changes.

This study identifies Pinch2 as a critical regulator of central nervous system myelination, showing that its loss leads to hypermyelination and pathological myelin outfoldings.

This study shows Rac1 in microglia is crucial for synaptic proteome plasticity and cognitive performance through homeostatic regulation and synapse communication.

This study shows that Meth exposure causes microglia reactivity through astrocyte-derived TNF and glutamate, affecting behavior in adult mice.

The paper compares the proteome of remyelination and developmental myelination in mice, finding distinct protein compositions and identifying potential therapeutic targets.

The paper investigates the role of the Pebble/Rho1/Anillin pathway in glial cell proliferation and polyploidization in Drosophila eye development, showing it prevents large polyploid glial cells but is not required for axonal wrapping.

This study shows that alcohol intake causes excessive synaptic pruning by microglia, leading to synapse loss and anxiety-like behavior.

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.