Sandra Henriques Vaz

Stem-cell modeling of cerebellar dysfunction of Angelman syndrome

This study uses stem cell-derived cerebellar organoids to model Angelman syndrome, revealing impaired development and neuronal dysfunction in cerebellar cells.

Mitochondria at synapse utilize fatty acids as a bioenergetic fuel source

This study shows synaptic mitochondria prefer fatty acids over glucose for energy production, enhancing respiratory flexibility and ATP content in neurons.

Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress

This study shows that inhibiting cannabinoid type 2 receptors combined with physical exercise reduces stress-induced emotional and cognitive deficits and enhances adult hippocampal neurogenesis.

Unravelling a novel role for Cannabidivarin in the modulation of subventricular zone postnatal neurogenesis

This study investigates CBDV's effect on SVZ neurogenesis, showing it promotes neuronal differentiation and inhibits oligodendrocyte differentiation via TRPV1.

Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for lipid raft dynamics in early metaplasticity.

The paper investigates how epileptiform activity affects theta-burst induced LTP in rat hippocampal slices and identifies changes in lipid raft markers associated with early metaplasticity.

Changes in adenosine and neurotrophic signaling in the SOD1G93A mouse model of amyotrophic lateral sclerosis: modulation by chronic caffeine intake

This study examines adenosine and VEGF signaling changes in SOD1G93A mice with and without chronic caffeine treatment, finding early adenosinergic dysfunction and caffeine's impact on BDNF levels.

Astrocytes are implicated in BDNF-mediated enhancement of hippocampal long-term potentiation

This study shows that astrocytes are necessary for BDNF-enhanced hippocampal LTP, but only under specific stimulation conditions.

Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.