Author

Aaron M.N. Joiner

QB3ORCID 0000-0001-9049-2384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aniketh BishnuiD· 1 shared Erika L.F. HolzbauriD· 1 shared Ian G. GanleyiD· 1 shared Isaac J. AlleniD· 1 shared James H. HurleyiD· 1 shared Julia F. RileyiD· 1 shared Minghao CheniD· 1 shared Qingyang NiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Aniketh BishnuORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintAug 10, 2026

Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagy

Minghao Chen, Aniketh Bishnu, Yongjia Duan…·James H. Hurley

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

DOI 10.64898/2026.08.07.743589

humancryo-EM

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