Aniketh Bishnu

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

This study shows that AMPK senses NAD levels, with NAD binding to the gamma subunit and modulating AMPK activity, which affects metabolic pathways like mTORC1 and autophagy.

This study shows that activating AMPK reduces excessive mitophagy and restores mitochondrial function in FBXL4-related mitochondrial DNA depletion syndrome models.