Author

Minghao Chen

QB3ORCID 0000-0002-7668-3974Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Minghao Chen1 paper · East China University of Science and Technology

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Aaron M.N. JoineriD· 1 shared Andrea OeckinghausiD· 1 shared Aniketh BishnuiD· 1 shared Björn Udo KlinkiD· 1 shared Christos GatsogiannisiD· 1 shared Daniel KümmeliD· 1 shared Erika L.F. HolzbauriD· 1 shared Esther Michalke· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

Aaron M.N. JoinerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 10, 2026

Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagy

Minghao Chen, Aniketh Bishnu, Yongjia Duan…·James H. Hurley

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

DOI 10.64898/2026.08.07.743589

BiochemistryNature CommunicationsPeer-reviewedJul 30, 2025

Structure and mechanism of the RalGAP tumor suppressor complex

René Rasche, Björn Udo Klink, Lisa Helene Apken…·Daniel Kümmel

This study presents the cryo-EM structure of the RalGAP tumor suppressor complex, revealing its tetrameric architecture and providing insights into its function and relevance in cancer.

3 citations

cryo-EMexperimental assay