Qingyang Ni

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Over 8,000 gapless human centromeres reveal population-stratified satellite-array, inversion and haplotype variation, multiple candidate kinetochore sites in 16.8% of centromeres, and single-base substitution rates comparable to flanking pericentromeres.

This study benchmarks APA detection tools in single-cell and spatial transcriptomes, finding SCAPE and scAPAtrap perform best across multiple metrics.

This study systematically analyzes single-cell data to show how transposable elements dynamically regulate the endothelial-to-hematopoietic transition through epigenetic changes and inflammatory signaling.