Aravind Lathika Rajendrakumar

Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in the NECTIN2 Gene and Alzheimer's Disease: New Findings from Causal Mediation Analysis of ADNI Data

The paper uses causal mediation analysis on ADNI data to show that hippocampal volume mediates the link between NECTIN2 rs6859 polymorphism and Alzheimer's disease risk.

Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C and APOE4 add to this association

This study finds that high blood glucose levels are associated with brain hypometabolism progression, with HDL-C and APOE4 further contributing to this association.

APOE4 and Infectious Diseases Jointly Contribute to Brain Glucose Hypometabolism, a Biomarker of Alzheimers Pathology: New findings from the ADNI

The paper investigates how APOE4 and infections together contribute to brain glucose hypometabolism, a marker of Alzheimer's pathology, using ADNI data.

The association between rs6859 in NECTIN2 gene and Alzheimers disease is partly mediated by pTau

This study finds that the AD risk SNP rs6859 in NECTIN2 partly mediates its association with AD through increased pTau-181 levels in CSF.

Multi-ancestry genome-wide association study of neutrophil-lymphocyte ratio and polygenic risk score development to explore causal association with diabetic retinopathy

This paper conducts a multi-ancestry GWAS to identify genetic loci influencing NLR and develops a PRS to assess its causal association with DR, finding no significant causal link.

A meta-analysis of the genome-wide association studies on two genetically correlated phenotypes (self-reported headache and self-reported migraine) identifies four new risk loci for headaches (N=397,385)

This study performs a meta-analysis of GWAS on self-reported headache and migraine, identifying four new risk loci for headaches using 397,385 samples.

Genetic correlations between pain phenotypes and depression and neuroticism

This study identifies genetic correlations between eight pain phenotypes and depression, major depressive disorders, and neuroticism using UK Biobank data and LDSC methods.