Sachdev S. Sidhu

The paper uses biased Fab phage-display libraries and computational methods to identify potent serine protease inhibitors and validate their binding interactions.

This paper describes the engineering of high-affinity 3-phosphohistidine-specific antibodies using phage display and validates their utility in detecting pHis proteins in mammalian cells.

This study demonstrates promising preclinical efficacy of aITGB2-targeted radiotheranostics for selective imaging and therapy in AML.

The paper identifies ubiquitin variants that inhibit Ube2d2, showing structural and biophysical properties that suggest potential for developing selective E2 enzyme inhibitors.

This paper identifies engineered ubiquitin variants that suppress Salmonella NEL SspH1 toxicity in yeast by modulating ubiquitination activity and cell cycle interference.

The paper identifies a WNT7A-FZD5 signaling axis critical for human fallopian tube stem cell self-renewal using single-cell transcriptomics and organoid models.

This paper describes the engineering of peptide-antibody fusions using phage display to enhance neutralization potency and breadth against SARS-CoV-2 variants.

This paper develops tetravalent SARS-CoV-2 neutralizing antibodies that are more potent and resistant to escape mutations than bivalent versions.

This study identifies ACE2 receptor polymorphisms that may influence susceptibility to SARS-CoV-2 by altering the interaction between ACE2 and the viral S-protein.

This study identifies RIN/G3BP-bound mRNAs in Drosophila and shows they are short, stable, and highly translated, suggesting RIN stabilizes and enhances their translation.