Author

Shane Miersch

University of TorontoORCID 0000-0003-4785-4508Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Reza Saberianfar· 3 shared Sachdev S. SidhuiD· 3 shared Alevtina Pavlenco· 2 shared Chao CheniD· 2 shared Daisy W. LeungiD· 2 shared Gaya K. AmarasingheiD· 2 shared Giuseppe NovelliiD· 2 shared Mart UstaviD· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersSynthetic Biology

Reza Saberianfar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Synthetic BiologyACS Chemical BiologyPeer-reviewedJun 22, 2022

Peptide-antibody Fusions Engineered by Phage Display Exhibit Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants

Jonathan M. Labriola, Shane Miersch, Gang Chen…·Sachdev S. Sidhu

This paper describes the engineering of peptide-antibody fusions using phage display to enhance neutralization potency and breadth against SARS-CoV-2 variants.

16 citations

experimental assay

𝕏 PostBluesky

Synthetic BiologyJournal of Molecular BiologyPeer-reviewedJul 28, 2021

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Shane Miersch, Zhijie Li, Reza Saberianfar…·Sachdev S. Sidhu

This paper develops tetravalent SARS-CoV-2 neutralizing antibodies that are more potent and resistant to escape mutations than bivalent versions.

45 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

GeneticsCommunications BiologyPeer-reviewedApr 12, 2021

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

Kushal Suryamohan, Devan C. Diwanji, Eric W. Stawiski…·Somasekar Seshagiri

This study identifies ACE2 receptor polymorphisms that may influence susceptibility to SARS-CoV-2 by altering the interaction between ACE2 and the viral S-protein.

299 citationstop 1%

humanwhole-genome sequencing

𝕏 PostBluesky