Author

Jonathan M. L. Ostrem

University of California, San FranciscoORCID 0000-0001-9085-1615Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

Weicheng LiiD· 2 shared Aidan KeithiD· 1 shared Changliang He· 1 shared Colton M. SandersiD· 1 shared Dominique C. MitchelliD· 1 shared Gary K.L. ChaniD· 1 shared Hannah R. AllegakoeniD· 1 shared Jezrael L. RevaldeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Weicheng LiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 3, 2026

Fluorescence polarization-based fragment screen identifies inhibitors of APOBEC3A and APOBEC3B

Julianna S. Brunello, Hannah R. Allegakoen, Weicheng Li…·Jonathan M. L. Ostrem

This study identifies small molecule inhibitors of APOBEC3A and APOBEC3B using a fluorescence polarization assay, revealing compounds that disrupt DNA interactions and deaminase activity.

DOI 10.64898/2026.07.31.742089

humanproteomics

𝕏 PostBluesky

BiochemistryCell chemical biologyPeer-reviewedAug 1, 2026

Small molecule activation of the tumor suppressor kinase LKB1

Lin Song, Dominique C. Mitchell, Jin Liu…·John Dozier Gordan

This study develops small molecules that activate the tumor suppressor kinase LKB1 and shows their therapeutic benefits in cancer cell lines.

3 citations

humanexperimental assay

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