This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

Kidney International · Apr 27, 2026Peer-reviewedCell Biology

Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules

Mahla Asghari, Angela R. Sabo, Daria Barwinska, Ricardo Melo Ferreira, Michael J. Ferkowicz, William S. Bowen, Ying‐Hua Cheng, Debora L. Gisch, Connor J. Gulbronson, Carrie L. Phillips, Katherine J. Kelly, Timothy A. Sutton, James C. Williams, Miguel A. Vazquez, John O’Toole, , Pierre C. Dagher

bioRxiv · Nov 26, 2024 · PreprintBioinformatics

The chromatin landscape of healthy and injured cell types in the human kidney

Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine M. Basta, Mark S. Keller, Ricardo Melo Ferreira, Shreeram Akilesh, Reetika R. Ghag, Charles Lu, Ying‐Hua Cheng, Kimberly S. Collins, Samir V. Parikh, Brad H. Rovin, Lynn Robbins, Lisa Stout, , Joana P. Gonçalves

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

Nature Communications · Jan 10, 2024Peer-reviewedMolecular Biology

Alterations in protein translation and carboxylic acid catabolic processes in diabetic kidney disease

Kimberly S. Collins, Michael T. Eadon, Ying‐Hua Cheng, Daria Barwinska, Ricardo Melo Ferreira, Thomas W. McCarthy, Danielle Janosevic, Farooq Syed, Bernhard Maier, Tarek M. El‐Achkar, Katherine J. Kelly, Carrie L. Phillips, Takashi Hato, Timothy A. Sutton, Pierre C. Dagher

The paper identifies altered protein translation and carboxylic acid catabolism in diabetic kidney disease using human and mouse models.

Cells · Mar 30, 2022Peer-reviewedSystems Biology