Author
University of WashingtonORCID 0000-0002-5565-2685Unclaimed ORCID profile · follow to get notified of new preprints
13 papers
Recent·Most cited
Dongmin R. Son, Yong‐Hwee Eddie Loh, Hyeonsoo Jeong, Jian Ma, Evan E. Eichler, Soojin V. Yi
The paper shows that peri/centromeric regions in ape genomes are hypomethylated CpG reservoirs, linking germline hypomethylation to CpG evolution and structural transcriptomic innovation.
bioRxiv · Oct 4, 2026 · PreprintGenomics
Hyeonsoo Jeong, Blue B. Lake, Dinh H. Diep, Xuwen Li, Qi Jiang Yan, Debora L. Gisch, Stephanie Reinert, Michael T. Eadon, Joseph P. Gaut, S V Jain, Kun Zhang
The paper builds a cross-species single-cell multi-omics kidney atlas to identify epithelial cells as a driver of epigenetic aging in diseased kidneys.
bioRxiv · Jan 23, 2026 · PreprintGenomics
Xavi Guitart, Jessie Brunner, Luyao Ren, Hyeonsoo Jeong, DongAhn Yoo, David Porubskỳ, Kendra Hoekzema, Katherine M. Munson, Kaitlyn A. Sun, Marcelo Ayllon, Kaylynn Hoglin, Reed McMullen, Bryan J. Pavlovic, Mitchell Robert Vollger, Alex A. Pollen, Evan E. Eichler
The paper identifies a segmental duplication that drives position effect expression of TBC1D3 in the human brain, explaining its high structural heterozygosity.
bioRxiv · Jan 15, 2026 · PreprintGenomics
David Porubskỳ, Harriet Dashnow, Thomas A. Sasani, Glennis A. Logsdon, Pille Hallast, Michelle D. Noyes, Zev N. Kronenberg, Tom Mokveld, Nidhi Koundinya, Cillian Nolan, Cody J. Steely, Andrea Guarracino, Egor Dolzhenko, William T. Harvey, William J. Rowell, , Evan E. Eichler
The paper uses a four-generation family to systematically assess de novo mutations and recombination, finding high mutation rates and paternal bias, along with a detailed recombination map.
Nature · Apr 23, 2025Peer-reviewedGenomics
DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N Sequeira, , Zhenmiao Zhang
The paper presents haplotype-resolved genomes of six ape species with high accuracy and provides comparative analyses to study evolutionary diversity and gene family evolution.
Nature · Apr 9, 2025Peer-reviewedGenomics
Hyeonsoo Jeong, Philip C. Dishuck, DongAhn Yoo, William T. Harvey, Katherine M. Munson, Alexandra P. Lewis, Jennifer Kordosky, Gage H. Garcia, Feyza Yilmaz, Pille Hallast, Charles Lee, Tomi Pastinen, Evan E. Eichler
The paper analyzes segmental duplications in human genomes using long-read sequencing, identifying structurally polymorphic events and novel genes associated with copy number variation.
Nature Genetics · Jan 8, 2025Peer-reviewedGenomics
Hyeonsoo Jeong, Isabel Mendizabal, Soojin V. Yi
This study identifies age-related DNA methylation changes in neurons and oligodendrocytes, showing that epigenetic drift is a stronger predictor of methylation variation than sex or disease.
GeroScience · Dec 27, 2024Peer-reviewedGenetics
David Pellerin, Giulia F. Del Gobbo, Madeline Couse, Egor Dolzhenko, Sathiji Nageshwaran, Warren Cheung, Isaac R. L. Xu, Marie‐Josée Dicaire, Guinevere Spurdens, Gabriel E. Matos-Rodrigues, Igor Stevanovski, Carolin K. Scriba, Adriana P. Rebelo, Virginie Roth, Marion Wandzel, , Alba Sanchis‐Juan
The paper identifies a common flanking variant linked to increased meiotic stability at the FGF14-SCA27B repeat locus.
Nature Genetics · Jun 27, 2024Peer-reviewedGenetics
Kateryna D. Makova, Brandon D. Pickett, Robert S. Harris, Gabrielle A. Hartley, Monika Čechová, Karol Pál, Sergey Nurk, DongAhn Yoo, Qiuhui Li, Prajna Hebbar, Barbara C. McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, , Adam M. Phillippy
The paper produces gapless assemblies of ape sex chromosomes for five great apes and a lesser ape, revealing divergence in Y chromosomes and evolutionary dynamics.
Nature · May 29, 2024Peer-reviewedGenomics
Yafei Mao, William T. Harvey, David Porubskỳ, Katherine M. Munson, Kendra Hoekzema, Alexandra P. Lewis, Peter A. Audano, Allison N. Rozanski, Xiangyu Yang, Shilong Zhang, DongAhn Yoo, David Gordon, Tyler Fair, Xiaoxi Wei, Glennis A. Logsdon, , Evan E. Eichler
The paper identifies structurally divergent regions in primate genomes and quantifies the impact of structural variants across multiple species.
Cell · Feb 29, 2024Peer-reviewedGenomics
Dan Sun, Thomas S. Layman, Hyeonsoo Jeong, Paramita Chatterjee, Kathleen E. Grogan, Jennifer R. Merritt, Donna L. Maney, Soojin V. Yi
The paper shows DNA methylation changes linked to development and chromosomal suppression of recombination in white-throated sparrows, with implications for genome integrity and gene expression.
Molecular Ecology · Jan 14, 2021Peer-reviewedGenomics
Hyeonsoo Jeong, Isabel Mendizabal, Stefano Berto, Paramita Chatterjee, Thomas S. Layman, Noriyoshi Usui, Kazuya Toriumi, Connor Douglas, Devika Singh, Iksoo Huh, Todd M. Preuss, Geneviève Konopka, Soojin V. Yi
The paper investigates DNA methylation evolution in human brain cells, showing reduced CG methylation and increased CH methylation, linked to schizophrenia risk.
bioRxiv · Jul 14, 2020 · PreprintGenomics
Isabel Mendizabal, Stefano Berto, Noriyoshi Usui, Kazuya Toriumi, Paramita Chatterjee, Connor Douglas, Iksoo Huh, Hyeonsoo Jeong, Thomas S. Layman, Carol A. Tamminga, Todd M. Preuss, Geneviève Konopka, Soojin V. Yi
The paper analyzes cell-type specific DNA methylation and transcriptomes in schizophrenia brains, finding reduced epigenetic distinction between cell types in schizophrenia.
Genome biology · Jul 9, 2019Peer-reviewedGenomics